Anemia, Immune system, seborrheic dermatitis
Vitamin B6, also known as pyridoxine, play a role in various metabolic pathways, such as amino acid conversion, synthesis of hemoglobin, and synthesis of neurotransmitters like dopamine and serotonin.
Deficiency in vitamin B6 can lead to sleepiness and fatigue, anemia, seborrheic dermatitis and skin problems, high homocysteine levels, impaired immune system and neurological problems.
ALPL is the major enzyme involved in the clearance of vitamin B6.
Gene: ALKALINE PHOSPHATASE, LIVER; ALPL
Genomic coordinates (GRCh38): 1:21,508,981-21,578,411
Allele carriers show a more efficient clearance rate of the vitamin. This variant is very common in the population, and can be found in close to 50% of the population. Carriers of one copy of the variant show up to 18% lower vitamin B6 levels. However, homozygotes individuals show up to 42% lower levels, and are clinically at risk for B6 deficiency.